The calcitonin receptor is a GPCR in the same group B sub-family that also includes the receptors for vasoactive intestinal peptide, secretin, and PTH and PTHrP. This receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. This gene encodes a high affinity receptor for the peptide hormone Calcitonin. The protein plays an important role in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Calcitonin Receptor is able to decrease blood calcium levels by both; direct inhibition of mediated bone resorption and also by enhancing calcium excretion by the kidney. Green Fluorescent Calcitonin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as calcitonin.
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