Green Fluorescent CCR2 Chemokine Receptor Cell Line

Reference: P30272

6.950,00€

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent CCR2 Chemokine Receptor Cell Line contains U2OS cells stably expressing CCR2 tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent CCR2 Chemokine Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CCR2 activation and the following redistribution process inside the cells. When a ligand binds to the CCR2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CCR2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring CCR2 Receptor redistribution process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×10⁶ cells / vial

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 plays an important role in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. An excessive monocytes infiltration generates higher inflammation and increases the risk of heart failure. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. Green Fluorescent CCR2 Chemokine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as MCP-1.

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Reference: P30272
Size/Quantity: 2 vials containing 3x10⁶ cells / vial
Product Use: For research use only
Shipping Conditions: Dry Ice

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