Green Fluorescent CRF2 Receptor Cell Line

Reference: P30216

Green Fluorescent CRF2 Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent CRF2 Cell Line contains CHO-K1 cells stably expressing CRF2 tagged with tGFP.  These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent CRF2 Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CRF2 activation and the following redistribution process inside the cells. When a ligand binds to the CRF2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CRF2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring CRF2 Receptor redistribution process in High Throughput Screening.


Size/Quantity: 2 vials containing 3×106 cells / vial


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CRF2 is the gene that encodes a protein also known as CRHR-2. The CRF Receptor family is a group of G-coupled receptors that shows high affinity for CRH. CRH is a polypeptide hormone and neurotransmitter synthesized in the hypothalamus that is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis. CRH plays an important role in the stress response and the stimulation of the pituitary synthesis of ACTH (Adrenocorticotropic hormone). Green Fluorescent CRF2 Receptor Cell Line allows the measurement of the activity of ligands; such as CRF.

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  • Reference: P30216
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice

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