The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is member of Alpha-1-adrenergic receptors (alpha-1-ARs) family. They activate mitogenic responses and regulate growth and proliferation of many cells. The primary transduction mechanism is mediated by Gq/G11 family transducers; so its activation response is easily measured by calcium flux. HiTSeeker alpha1B Adrenergic Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as epinephrine.
HiTSeeker alpha1B Adrenergic Receptor Cell Line
Reference: P30141
HiTSeeker alpha1B Adrenergic Receptor Cell Line
HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker alpha1B Adrenergic Receptor Cell Line contains U2OS cells stably expressing ADRA1B with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.
Innoprot HiTSeeker ADRA1B Cell Line allows to assay compounds, or analyze their capability to modulate ADRA1B. When a ligand binds to the ADRA1B, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker ADRA1B cell line has been validated measuring calcium concentration changes in the cytosol upon activation with epinephrine. The high reproducibility of this assay allows monitoring ADRA1B receptor activation process in High Throughput Screening.
Size/Quantity: 2 vials containing 3×106 cells / vial
5.250,00€
- Product Description
- Specifications
- Characterization
- Similars
- Publications
- Technical Resources & Protocols
- Reference: P30141
- Size/Quantity: 2 vials containing 3x106 cells / vial
- Product Use: For research use only
- Shipping Conditions: Dry Ice
