MC4R is a membrane-bound receptor and part of the Melanocortin Receptors family, that are members of the rhodopsin family receptors. MC4R binds adrenocorticotropic and α-melanocyte stimulating hormone (α-MSH) and plays important roles in a wide range of physiological functions, such as energy balance, metabolism regulation, feeding and sexual behaviour and erectile function. Mutations in its gene link with autosomal dominant obesity. It is mainly present in brain, placenta and intestinal tissue. When α-MSH binds to its receptor, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. HiTSeeker Melanocortin MC4 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as α-MSH.
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