Human Pulmonary Alveolar Epithelial Cells

Reference: P10556

Human Pulmonary Alveolar Epithelial Cells

Human Pulmonary Alveolar Epithelial Cells (HPAEpiC) provided by Innoprot are isolated from human healthy lung tissue. HPAEpiC are cryopreserved at passage 0 and delivered frozen. Each vial of Human Pulmonary Alveolar Epithelial Cells contains more than 1 million viable cells. HPAEpiC are guaranteed to further culture; however, HPAEpiC are not recommended for expanding or long-term cultures since the cells would differentiate to become type I alveolar epithelial cells immediately after plating and type I alveolar epithelial cells do not proliferate in culture.

Innoprot also offers optimized medium and reagents for the growth of Human Pulmonary Alveolar Epithelial Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HPAEpiC culture.


Size/Quantity: 1 million Cells / vial


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Human Pulmonary alveolar epithelial cells (PAEpiC), comprised of alveolar type I and type II epithelial cells, line more than 99% of the internal surface area of the lung. Type I cells are large squamous cells whose thin cytoplasmic extensions cover >95% of the internal surface area. They contain aquaporins and exhibit the highest osmotic water permeability of any mammalian cell type. Type II cells, which cover 2-5% of the surface area, produce, secrete, and recycle pulmonary surfactant. Type II cells contain Na+-, K+-ATPase and amiloride-sensitive epithelial Na+ channels. The currently accepted hypothesis is that Type II cells maintain pulmonary fluid homeostasis by regulating active Na+ transport in the lungs, whereas Type I cells are “inert” cells that provide solely a barrier function, rather than having active functions.

Recent studies indicate that Type I cells are also important in regulating ion and fluid transport. They are also useful tools to stablish in vitro disease models for High Throughput and High Content Screening.



  • Reference: P10556
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice