{"id":16423,"date":"2025-12-03T11:29:20","date_gmt":"2025-12-03T10:29:20","guid":{"rendered":"https:\/\/innoprot.com\/?p=16423"},"modified":"2026-01-19T13:29:14","modified_gmt":"2026-01-19T12:29:14","slug":"article-published-development-of-pleiotropic-trkb-and-5-ht4-receptor-ligands-as-neuroprotective-agents","status":"publish","type":"post","link":"https:\/\/innoprot.com\/es\/article-published-development-of-pleiotropic-trkb-and-5-ht4-receptor-ligands-as-neuroprotective-agents\/","title":{"rendered":"Article Published: Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents"},"content":{"rendered":"<p>One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal death. Endogenous neurotrophins consist of the major neuroprotective factors. Brain-derived neurotrophic factor (BDNF) and its high-affinity tyrosine kinase receptor TrkB are described in a number of studies for their important neuronal effects. Normal function of this receptor is crucial for neuronal survival, differentiation, and synaptic function. However, studies have shown that besides direct activation, the TrkB receptor can be transactivated via GPCRs.<\/p>\n<p>It has been proven that activation of the 5-HT<sub>4<\/sub> receptor and transactivation of the TrkB receptor have a positive influence on neuronal differentiation. This includes total dendritic length, number of primary dendrites, and branching index. Because of that and based on the main structural characteristics of LM22A-4, a known activator of the TrkB receptor, and RS67333, a partial 5-HT<sub>4<\/sub> receptor agonist, we have designed and synthesized a small data set of novel compounds. These compounds have been designed to have potential dual activity. The objective is not only to prevent neuronal death, but also to induce neuronal differentiation in neurodegenerative disorders.<\/p>\n<p><em>Molecules. <\/em>2024 Jan 19<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38276593\/\">More information<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal death. Endogenous neurotrophins consist of the major neuroprotective factors. Brain-derived neurotrophic factor (BDNF) and its high-affinity tyrosine kinase receptor TrkB are described in a number of studies for their important neuronal [&hellip;]<\/p>\n","protected":false},"author":9192194,"featured_media":16424,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1005],"tags":[],"class_list":["post-16423","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Article Published: Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents &#8212; Innoprot<\/title>\n<meta name=\"description\" content=\"Design and synthesis of novel TrkB and 5-HT4 receptor ligands with dual neuroprotective effects in neurodegenerative disorders.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/article-published-development-of-pleiotropic-trkb-and-5-ht4-receptor-ligands-as-neuroprotective-agents\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Article Published: Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents &#8212; 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