Innoprot offers SH-SY5Y stably expressing tau-tGFP & alpha-synuclein-TagRFP as valuable tools to use as \u201cin vitro\u201d models for research studies.<\/p>\n
Alpha-synuclein (also \u03b1-synuclein) is a protein whose function in the healthy brain is currently unknown. It is abundant in the brain but also appear smaller amounts in the heart, muscles, and other tissues. In the brain, alpha-synuclein appears mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals.<\/p>\n
Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles; and is therefore of major interest as an indicator of disease mechanisms. They are abundant in neurons of the central nervous system and are less common elsewhere; but also appears at very low levels in CNS astrocytes and oligodendrocytes. They accumulate in neurofibrillary tangles in Alzheimer’s disease (AD) brain. There is significant evidence that a disruption of normal phosphorylation events results in tau dysfunction. It is a contributing factor to the pathogenic processes of neurodegenerative diseases, such as AD.<\/p>\n","protected":false},"excerpt":{"rendered":"
A novel SH\u2010SY5Y cell line has been developed through stable transfection with tGPF\u2010tau protein (0N4R isoform-G272V mutation) and TagRFP\u2010\u03b1\u2010synuclein (wild type). This cell line is stably\u2010transfected with both construcst and it is ready to use in cell\u2010based assay applications. This stably transfected cell line provides consistent levels of expression, which helps to simplify the interpretation of the results. This cell line is intended to be used as an \u201cin vitro\u201d model for research studies.<\/p>\n
Each vial of this cell line stably expressing human tau(0N4R-G272V)-tGFP and TagRFP\u2010\u03b1\u2010synuclein contains 3 million cells. It is guaranteed that these cells will expand in more than 30 passages following the cell culture manual.<\/p>\n","protected":false},"featured_media":1248,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[114],"product_tag":[287,307,894,306,315],"class_list":["post-1247","product","type-product","status-publish","has-post-thumbnail","product_cat-stable-cell-lines-for-cns-research","product_tag-alzheimers-disease","product_tag-parkinsons-disease","product_tag-pd-cell-lines","product_tag-synuclein","product_tag-tau","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\n