{"id":1477,"date":"2019-02-26T19:30:52","date_gmt":"2019-02-26T18:30:52","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&p=1477"},"modified":"2019-12-12T11:21:36","modified_gmt":"2019-12-12T10:21:36","slug":"hitseeker-calcitonin-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/hitseeker-calcitonin-receptor-cell-line\/","title":{"rendered":"HiTSeeker Calcitonin Receptor Cell Line"},"content":{"rendered":"

The calcitonin receptor<\/span> is a GPCR in the same group B sub-family that also includes the receptors for vasoactive intestinal peptide, secretin, and PTH and PTHrP.\u00a0This receptor family comprises a group of receptors for the calcitonin\/CGRP family of peptides.\u00a0This gene encodes a high affinity receptor for the peptide hormone Calcitonin. The protein plays an important role in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Calcitonin Receptor is able to decrease blood calcium levels by both; direct inhibition of mediated bone resorption and also by enhancing calcium excretion by the kidney. HiTSeeker Calcitonin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as calcitonin.<\/p>\n","protected":false},"excerpt":{"rendered":"

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker calcitonin receptor Cell Line contains HEK293 cells stably expressing CALCR with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.<\/p>\n

Innoprot HiTSeeker Calcitonin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CALCR. When a ligand binds to the CALCR, it activates a G protein, which in turn, triggers a cellular response mediated by cAMP. HiTSeeker CALCR cell line has been validated measuring both, cAMP & Calcium concentration changes in the cytosol upon activation with calcitonin. The high reproducibility of this assay allows monitoring CALCR activation process in High Throughput Screening.<\/p>\n

Size\/Quantity<\/strong>: 2 vials containing 3×106<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1478,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[351],"product_tag":[436,430],"class_list":["post-1477","product","type-product","status-publish","has-post-thumbnail","product_cat-calcr","product_tag-calcitonin-receptor","product_tag-gpcr","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nHiTSeeker Calcitonin Receptor Cell Line — Innoprot GPCR Cell Line<\/title>\n<meta name=\"description\" content=\"Each vial of HiTSeeker calcitonin receptor Cell Line contains HEK293 cells stably expressing human calcitonin receptor with no tag\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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