{"id":1502,"date":"2019-02-26T23:24:11","date_gmt":"2019-02-26T22:24:11","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1502"},"modified":"2019-12-12T11:21:12","modified_gmt":"2019-12-12T10:21:12","slug":"hitseeker-muscarinic-acetylcholine-receptor-m1-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/hitseeker-muscarinic-acetylcholine-receptor-m1-cell-line\/","title":{"rendered":"HiTSeeker Muscarinic Acetylcholine Receptor M1 Cell Line"},"content":{"rendered":"<p>The muscarinic acetylcholine receptor family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1 receptor, along with the M3 and M5 receptors; signal through Gq\/11 and subsequent release of Calcium from the ER. The M1 receptor mediates depolarization of ganglia by inhibition of voltage-gated M-type K+ channels. In addition, the M1 receptor mediates venous contraction. The muscarinic cholinergic receptor 1 plays an important role in mediation of vagally-induced bronchoconstriction, but also in the acid secretion of the gastrointestinal tract. HiTSeeker Muscarinic Acetylcholine Receptor M1 Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as oxotremorine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker Muscarinic Acetylcholine Receptor M1 Cell Line contains U2OS cells stably expressing CHRM1 with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.<\/p>\n<p>Innoprot HiTSeeker Muscarinic Acetylcholine Receptor M1 Cell Line allows to assay compounds, or analyze their capability to modulate CHRM1. When a ligand binds to the CHRM1, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker CHRM1 cell line has been validated measuring calcium concentration changes in the cytosol upon activation with oxotremorine. The high reproducibility of this assay allows monitoring CHRM1 receptor activation process in High Throughput Screening.<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1503,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[388],"product_tag":[430,438],"class_list":["post-1502","product","type-product","status-publish","has-post-thumbnail","product_cat-m1-chrm1","product_tag-gpcr","product_tag-muscarinic-receptor","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HiTSeeker Muscarinic Acetylcholine Receptor M1 Cell Line &#8212; Innoprot<\/title>\n<meta name=\"description\" content=\"Each vial of HiTSeeker Muscarinic Acetylcholine Receptor M1 Cell Line contains 3 million U2OS cells stably expressing human CHMR1 with no tag\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/hitseeker-muscarinic-acetylcholine-receptor-m1-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HiTSeeker Muscarinic Acetylcholine Receptor M1 Cell Line &#8212; 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