{"id":1529,"date":"2019-02-27T15:19:21","date_gmt":"2019-02-27T14:19:21","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&p=1529"},"modified":"2019-12-12T11:25:24","modified_gmt":"2019-12-12T10:25:24","slug":"hitseeker-cb2-cannabinoid-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/hitseeker-cb2-cannabinoid-receptor-cell-line\/","title":{"rendered":"HiTSeeker CB2 Cannabinoid Receptor Cell Line"},"content":{"rendered":"

The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two cannabinoid receptors play and important role in the cannabinoid-induced CNS effects, including alterations in mood and cognition. Changes in endocannabinoid levels and\/or CB2<\/sub> receptor expressions have been reported in almost all diseases affecting humans; such as cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung disorders or pain and cancer. The prevalence of this trend suggests that modulating CB2<\/sub> receptor activity by either selective CB2<\/sub> receptor agonists or inverse agonists\/antagonists depending on the disease and its progression holds unique therapeutic potential for these pathologies. HiTSeeker CB2<\/sub> Cannabinoid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as CP55940.<\/p>\n","protected":false},"excerpt":{"rendered":"

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker CB2 Cannabinoid Receptor Cell Line contains HEK293 cells stably expressing CB2 with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.<\/p>\n

Innoprot HiTSeeker CB2 Cell Line allows to assay compounds, or analyze their capability to modulate CB2. When a ligand binds to the CB1, it activates a G protein, which in turn, triggers a cellular response mediated by a second messenger. HiTSeeker CB2 cell line has been validated performing an assay with [3H]CP55940 and increasing concentrations of no radioactive competitor. The high reproducibility of this assay allows monitoring CB2 receptor activation process in High Throughput Screening.<\/p>\n

Size\/Quantity<\/strong>: 2 vials containing 3×106<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1530,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[354],"product_tag":[439,430],"class_list":["post-1529","product","type-product","status-publish","has-post-thumbnail","product_cat-cb2","product_tag-cannabinoid-receptor","product_tag-gpcr","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nHiTSeeker CB2 Cannabinoid Receptor Cell Line — Innoprot GPCR Cell Line<\/title>\n<meta name=\"description\" content=\"Each vial of HiTSeeker CB2 Cannabinoid Receptor Cell Line contains 3 million cells HEK293 cells stably expressing human CNR2 with no tag\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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