{"id":1592,"date":"2019-02-28T13:24:32","date_gmt":"2019-02-28T12:24:32","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&p=1592"},"modified":"2019-12-12T11:17:28","modified_gmt":"2019-12-12T10:17:28","slug":"hitseeker-lhcgr-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/hitseeker-lhcgr-cell-line\/","title":{"rendered":"HiTSeeker LHCGR Cell Line"},"content":{"rendered":"

The luteinizing hormone\/choriogonadotropin receptor (LHCGR), also lutropin\/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR) is a transmembrane receptor present predominantly in the ovary and testis, but also in many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans). Its activation is necessary for the hormonal functioning during reproduction. In women, the hormone stimulates the ovaries to produce oestradiol. Two weeks into a woman’s cycle, a surge in luteinizing hormone causes the ovaries to release an egg during ovulation. If fertilization occurs, luteinizing hormone will stimulate the corpus luteum, which produces progesterone to sustain the pregnancy. Both hormones stimulates gonadal function in assisted conception techniques such as in vitro fertilisation (IVF).\u00a0HiTSeeker LHCGR Cell Line from Innoprot allows the measurement of the activity and potency of ligands, such as recombinant human CG (rhCG).<\/p>\n

Click Here<\/a> to know more about LHCGR Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker LHCGR Cell Line contains HEK293 cells stably expressing human Luteinizing Hormone-Choriogonadotropin Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.<\/p>\n

Innoprot HiTSeeker LHCGR Cell Line allows to assay compounds, or analyze their capability to modulate LHCGR. When a ligand binds to the LHCGR, it activates a G protein, which in turn, triggers a cellular response mediated by second messengers (cAMP). HiTSeeker LHCGR cell line has been validated measuring cAMP concentration changes in the cytosol upon activation with rhCG. The high reproducibility of this assay allows monitoring LHCG receptor activation process in High Throughput Screening.<\/p>\n

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