{"id":1608,"date":"2019-02-28T15:09:38","date_gmt":"2019-02-28T14:09:38","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&p=1608"},"modified":"2019-12-12T11:17:08","modified_gmt":"2019-12-12T10:17:08","slug":"hitseeker-lpa3-lysophospholipid-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/hitseeker-lpa3-lysophospholipid-receptor-cell-line\/","title":{"rendered":"HiTSeeker LPA3 Lysophospholipid Receptor Cell Line"},"content":{"rendered":"

Lysophosphatidic acid (LPA; 1- or 2-acyl-sn<\/em>-glycerol-3-phosphate) is a phospholipid that plays roles in numerous normal physiological and pathological processes; such as brain development, blood vessel formation, embryo implantation, hair growth, neuropathic pain, lung fibrosis and colon cancer. Among the LPA receptors, LPA3<\/sub> is unique in that a specific form of LPA (2-acyl LPA with unsaturated fatty acids) activates it. It is also present in a limited number of tissues such as the reproductive organs. LPA3<\/sub>-mediated LPA signaling is essential for proper embryo implantation.\u00a0HiTSeeker LPA3 Lysophospholipid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as LPA.<\/p>\n

Click HERE<\/a> to know more about LPA3 Lysophospholipid Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker LPA3 Lysophospholipid Receptor Cell Line contains U2OS cells stably expressing LPA3 Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.<\/p>\n

Innoprot HiTSeeker LPA3 Lysophospholipid Receptor Cell Line allows to assay compounds, or analyze their capability to modulate LPA3 receptor. When a ligand binds to the LPA3R, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker LPA3 Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with LPA. The high reproducibility of this assay allows monitoring LPA3 Receptor activation process in High Throughput Screening.<\/p>\n

Size\/Quantity<\/strong>: 2 vials containing 3×106<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1609,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[381],"product_tag":[430,450],"class_list":["post-1608","product","type-product","status-publish","has-post-thumbnail","product_cat-lpa3","product_tag-gpcr","product_tag-lysophospholipid","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nHiTSeeker LPA3 Lysophospholipid Receptor Cell Line — Innoprot Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of HiTSeeker LPA3 Lysophospholipid Receptor Cell Line contains 3 million U2OS cells stably expressing human LPA3 receptor with no tag\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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