{"id":1658,"date":"2019-03-01T00:45:57","date_gmt":"2019-02-28T23:45:57","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&p=1658"},"modified":"2019-12-12T11:09:55","modified_gmt":"2019-12-12T10:09:55","slug":"hitseeker-nk1-tachykinin-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/hitseeker-nk1-tachykinin-receptor-cell-line\/","title":{"rendered":"HiTSeeker NK1 Tachykinin Receptor Cell Line"},"content":{"rendered":"

The tachykinin receptor NK1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. The NK1 receptor is present in both the central and peripheral nervous system. This receptor is an attractive drug target, particularly with regards to potential analgesics and anti-depressants. It is also a potential treatment for alcoholism and opioid addiction. In addition, it is a candidate in the etiology of bipolar disorder. Finally NK1R antagonists may also have a role as novel antiemetics and hypnotics.\u00a0HiTSeeker NK1 Tachykinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Substance P.<\/p>\n

Click HERE<\/a> to know more about NK1 Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker NK1 Tachykinin Receptor Cell Line contains HEK293 cells stably expressing NK1 Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.<\/p>\n

Innoprot HiTSeeker NK1 Tachykinin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate NK1 receptor. When a ligand binds to the NK1R, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker NK1 Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with Substance P. The high reproducibility of this assay allows monitoring NK1 Receptor activation process in High Throughput Screening.<\/p>\n

Size\/Quantity<\/strong>: 2 vials containing 3×106<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1659,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[418],"product_tag":[430,455],"class_list":["post-1658","product","type-product","status-publish","has-post-thumbnail","product_cat-tacr1-nk1","product_tag-gpcr","product_tag-tachykinin","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"\nHiTSeeker NK1 Tachykinin Receptor Cell Line — Innoprot GPCR Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of HiTSeeker NK1 Tachykinin Receptor Cell Line contains 3 million HEK293 cells stably expressing human NK1R receptor with no tag\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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