{"id":1720,"date":"2019-03-02T11:17:34","date_gmt":"2019-03-02T10:17:34","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1720"},"modified":"2025-12-01T14:12:06","modified_gmt":"2025-12-01T13:12:06","slug":"mpxnomad-cb1-cannabinoid-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-cb1-cannabinoid-receptor-cell-line\/","title":{"rendered":"<sub>MPX<\/sub>NOMAD CB1 Cannabinoid Receptor Cell Line"},"content":{"rendered":"<p>The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two cannabinoid receptors play and important role in the cannabinoid-induced CNS effects, such as alterations in mood and cognition. CB<sub>1<\/sub> receptors appear in the CNS and are responsible for mediating the effects of cannabinoid binding in the brain. Depolarized neurons release endocannabinoids, which bind to CB<sub>1<\/sub> receptors on pre-synaptic glutamatergic and GABAergic neurons, resulting in a respective decrease in either glutamate or GABA release. <sub>MPX<\/sub>NOMAD CB1 Cannabinoid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as CP55940.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=56\">HERE<\/a> to know more about CB1 Cannabinoid Receptor.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p><sub>MPX<\/sub>NOMAD Cells are cell lines stably co-expressing tag-free GPCRs and two Nomad Biosensors to monitor G-protein and \u03b2-arrestin modulation. Each vial of <strong><sub>MPX<\/sub>NOMAD\u00a0CB1 Cannabinoid Receptor Cell Line<\/strong> contains HEK293 cells stably expressing the following constructs:<\/p>\n<ul>\n<li>human \u03b11B-adrenoceptor with no tag<\/li>\n<li>cAMP Nomad Biosensor (Red Fluorescence)<\/li>\n<li>\u03b2-arrestin Nomad Biosensor (Green Fluorescence)<\/li>\n<\/ul>\n<p><strong><sub>MPX<\/sub>NOMAD CB1 Cannabinoid Receptor Cell Line<\/strong> allows to assay compounds analyzing both signalling pathways involving receptor activation; G protein by cAMP flux and \u03b2-arrestin recruitment, hence allowing biased activity studies. When an agonist binds to CB1 a G protein is activated which, in turn, triggers a cellular response mediated by cAMP and a subsequent internalization mediated by \u00df-Arrestin. This leads to an increase of fluorescence intensity of both \u03b2-Arrestin and cAMP biosensors. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":3874,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[353],"product_tag":[439,430,458],"class_list":["post-1720","product","type-product","status-publish","has-post-thumbnail","product_cat-cb1","product_tag-cannabinoid-receptor","product_tag-gpcr","product_tag-nomad-cell-lines","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MPXNOMAD CB1 Cannabinoid Receptor Cell Line &#8212; Nomad Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of MPX-NOMAD CB1 Cannabinoid Receptor Cell Line contains HEK293 cells expressing CB1 receptor &amp; 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