{"id":1749,"date":"2019-03-03T22:23:50","date_gmt":"2019-03-03T21:23:50","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1749"},"modified":"2025-12-01T14:05:28","modified_gmt":"2025-12-01T13:05:28","slug":"green-fluorescent-beta-2-adrenoreceptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-beta-2-adrenoreceptor-cell-line\/","title":{"rendered":"Green Fluorescent beta-2 adrenoreceptor Cell Line"},"content":{"rendered":"<p>The beta-2 adrenergic receptor (\u03b22 adrenoreceptor); also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor. It interacts with (binds) epinephrine; a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increased cAMP, and downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Green Fluorescent beta-2 adrenoreceptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as isoproterenol.There are three differentes types of Beta2-agonists; those which directly activate the receptor (salbutamol\/terbutaline), those which are present into a membrane depot (formoterol) and those which interact with a receptor-specific, auxiliary binding site (salmeterol). These differences in mechanism of action reflect the kinetics of airway smooth muscle relaxation and bronchodilation in asthmatic patients.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=29\">HERE<\/a> to know more about \u03b2<sub>2<\/sub>-adrenoceptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of <strong>Green Fluorescent beta-2 adrenoreceptor Cell Line<\/strong> contains CHO-K1 cells stably expressing ADRB2 tagged with tGFP.\u00a0 These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.<\/p>\n<p>Innoprot <strong>Green Fluorescent beta-2 adrenoreceptor Cell Line<\/strong> allows to assay compounds, or analyze their capability to modulate ADRB2 activation and the following redistribution process inside the cells. When a ligand binds to the ADRB2, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent ADRB2 redistribution\u00a0by image analysis as an increment of fluorescent intensity of these vesicles. The high reproducibility of this assay allows monitoring ADRB2 receptor redistribution process in High Throughput Screening.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1750,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[343],"product_tag":[433,430],"class_list":["post-1749","product","type-product","status-publish","has-post-thumbnail","product_cat-adrb2","product_tag-adrenergic-receptor","product_tag-gpcr","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Green Fluorescent beta-2 adrenoreceptor Cell Line &#8212; Innoprot Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of Green Fluorescent beta-2 adrenoreceptor Cell Line contains CHO-K1 cells stably expressing Green Fluorescent human \u03b22-adrenoceptor.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-beta-2-adrenoreceptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Green Fluorescent beta-2 adrenoreceptor Cell Line &#8212; 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