{"id":1782,"date":"2019-03-04T21:43:22","date_gmt":"2019-03-04T20:43:22","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1782"},"modified":"2025-12-01T14:11:16","modified_gmt":"2025-12-01T13:11:16","slug":"green-fluorescent-calcitonin-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-calcitonin-receptor-cell-line\/","title":{"rendered":"Green Fluorescent Calcitonin Receptor Cell Line"},"content":{"rendered":"<p>The <span class=\"topic-highlight\">calcitonin receptor<\/span> is a GPCR in the same group B sub-family that also includes the receptors for vasoactive intestinal peptide, secretin, and PTH and PTHrP.\u00a0This receptor family comprises a group of receptors for the calcitonin\/CGRP family of peptides.\u00a0This gene encodes a high affinity receptor for the peptide hormone Calcitonin. The protein plays an important role in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Calcitonin Receptor is able to decrease blood calcium levels by both; direct inhibition of mediated bone resorption and also by enhancing calcium excretion by the kidney. Green Fluorescent Calcitonin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as calcitonin.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=43\">HERE<\/a> to know more about Calcitonin Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of\u00a0<strong>Green Fluorescent Calcitonin Receptor Cell Line<\/strong> contains CHO-K1 cells stably expressing CALCR tagged with tGFP.\u00a0 These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.<\/p>\n<p>Innoprot\u00a0<strong>Green Fluorescent Calcitonin Receptor Cell Line<\/strong> allows to assay compounds, or analyze their capability to modulate CALCR activation and the following redistribution process inside the cells. When a ligand binds to the CALCR, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CALCR redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring Calcitonin Receptor redistribution process in High Throughput Screening.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1783,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[351],"product_tag":[436,430],"class_list":["post-1782","product","type-product","status-publish","has-post-thumbnail","product_cat-calcr","product_tag-calcitonin-receptor","product_tag-gpcr","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Green Fluorescent Calcitonin Receptor Cell Line &#8212; Innoprot GPCR Cell Line<\/title>\n<meta name=\"description\" content=\"Each vial of Green Fluorescent Calcitonin Receptor Cell Line contains 3 million CHO-K1 cells stably expressing green fluorescent calcitonin receptor\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-calcitonin-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Green Fluorescent Calcitonin Receptor Cell Line &#8212; 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