{"id":1790,"date":"2019-03-04T21:54:40","date_gmt":"2019-03-04T20:54:40","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1790"},"modified":"2025-12-01T14:12:46","modified_gmt":"2025-12-01T13:12:46","slug":"green-fluorescent-cb2-cannabinoid-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-cb2-cannabinoid-receptor-cell-line\/","title":{"rendered":"Green Fluorescent CB2 Cannabinoid Receptor Cell Line"},"content":{"rendered":"<p>The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two cannabinoid receptors play and important role in the cannabinoid-induced CNS effects, including alterations in mood and cognition. Changes in endocannabinoid levels and\/or CB<sub>2<\/sub> receptor expressions are present in almost all diseases affecting humans; such as cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung disorders or pain and cancer. The prevalence of this trend suggests that modulating CB<sub>2<\/sub> receptor activity by either selective CB<sub>2<\/sub> receptor agonists or inverse agonists\/antagonists depending on the disease and its progression holds unique therapeutic potential for these pathologies. Green Fluorescent CB<sub>2<\/sub> Cannabinoid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as CP55940.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=57\">HERE<\/a> to know more about CB2 Cannabinoid Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of\u00a0<strong>Green Fluorescent CB2 Cannabinoid Receptor Cell Line<\/strong> contains CHO-K1 cells stably expressing CB2 tagged with tGFP.\u00a0 These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.<\/p>\n<p>Innoprot\u00a0<strong>Green Fluorescent CB2 Cannabinoid Receptor Cell Line<\/strong> allows to assay compounds, or analyze their capability to modulate CB2 activation and the following redistribution process inside the cells. When a ligand binds to the CB2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CB2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring CB2 Receptor redistribution process in High Throughput Screening.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":9785,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[354],"product_tag":[439,430],"class_list":["post-1790","product","type-product","status-publish","has-post-thumbnail","product_cat-cb2","product_tag-cannabinoid-receptor","product_tag-gpcr","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Green Fluorescent CB2 Cannabinoid Receptor Cell Line &#8212; Innoprot<\/title>\n<meta name=\"description\" content=\"Each vial of Green Fluorescent CB2 Cannabinoid Receptor Cell Line contains 3 million CHO-K1 cells stably expressing green fluorescent CB2 receptor\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-cb2-cannabinoid-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Green Fluorescent CB2 Cannabinoid Receptor Cell Line &#8212; 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