{"id":1800,"date":"2019-03-04T22:37:37","date_gmt":"2019-03-04T21:37:37","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1800"},"modified":"2025-12-01T14:15:09","modified_gmt":"2025-12-01T13:15:09","slug":"green-fluorescent-ccr2-chemokine-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-ccr2-chemokine-receptor-cell-line\/","title":{"rendered":"Green Fluorescent CCR2 Chemokine Receptor Cell Line"},"content":{"rendered":"<p>This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 plays an important role in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. An excessive monocytes infiltration generates higher inflammation and increases the risk of heart failure. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.\u00a0Green Fluorescent CCR2 Chemokine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as MCP-1.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=59\">HERE<\/a> to know more about CCR2 Chemokine Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of\u00a0<strong>Green Fluorescent CCR2 Chemokine Receptor Cell Line<\/strong> contains U2OS cells stably expressing CCR2 tagged with tGFP.\u00a0 These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.<\/p>\n<p>Innoprot\u00a0<strong>Green Fluorescent CCR2 Chemokine Receptor Cell Line<\/strong> allows to assay compounds, or analyze their capability to modulate CCR2 activation and the following redistribution process inside the cells. When a ligand binds to the CCR2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CCR2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring CCR2 Receptor redistribution process in High Throughput Screening.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1801,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[460],"product_tag":[439,430],"class_list":["post-1800","product","type-product","status-publish","has-post-thumbnail","product_cat-ccr2","product_tag-cannabinoid-receptor","product_tag-gpcr","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Green Fluorescent CCR2 Chemokine Receptor Cell Line &#8212; Innoprot<\/title>\n<meta name=\"description\" content=\"Each vial of Green Fluorescent CCR2 Chemokine Receptor Cell Line contains 3 million U2OS cells stably expressing CCR2 chemokine receptor tGFP tagged\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-ccr2-chemokine-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Green Fluorescent CCR2 Chemokine Receptor Cell Line &#8212; 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