{"id":1881,"date":"2019-03-06T11:12:07","date_gmt":"2019-03-06T10:12:07","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1881"},"modified":"2025-12-01T14:20:55","modified_gmt":"2025-12-01T13:20:55","slug":"green-fluorescent-kappa-opioid-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-kappa-opioid-receptor-cell-line\/","title":{"rendered":"Green Fluorescent Kappa Opioid Receptor Cell Line"},"content":{"rendered":"<p>Mu, delta and kappa opioid receptors are GPCRs, which play a central role in pain control. They are key players in hedonic homeostasis, mood and well-being. The three receptors and their endogenous opioid peptides also regulate responses to stress, and a number of peripheral physiological functions including respiratory, gastrointestinal, endocrine and immune processes. The \u03ba-opioid receptor (KOR) causing effects related to nociception, consciousness, motor control, and mood. Dysregulation of this receptor system plays an important role in alcohol and drug addiction. The KOR may provide a natural addiction control mechanism, and therefore, drugs that target this receptor may have therapeutic potential in the treatment of addiction. Fluorescent Kappa Opioid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Dynorphin.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=318\">HERE<\/a> to know more about Kappa Opioid Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of\u00a0<strong>Green Fluorescent Kappa Opioid Receptor Cell Line<\/strong> contains U2OS cells stably expressing KOR Receptor tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.<\/p>\n<p>Innoprot\u00a0<strong>Green Fluorescent Kappa Opioid Receptor Cell Line<\/strong> allows to assay compounds, or analyze their capability to modulate KOR Receptor activation and the following redistribution process inside the cells. When a ligand binds to the KOR Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent Kappa Opioid Receptor redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring KOR Receptor redistribution process in High Throughput Screening.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1882,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[398],"product_tag":[430,462],"class_list":["post-1881","product","type-product","status-publish","has-post-thumbnail","product_cat-kor","product_tag-gpcr","product_tag-opioid-receptor","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Green Fluorescent Kappa Opioid Receptor Cell Line &#8212; Innoprot Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of Green Fluorescent Kappa Opioid Receptor Cell Line contains 3 million U2OS cells stably expressing Kappa Opioid Receptor tGFP tagged\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/green-fluorescent-kappa-opioid-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Green Fluorescent Kappa Opioid Receptor Cell Line &#8212; 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