{"id":1957,"date":"2019-03-07T13:24:23","date_gmt":"2019-03-07T12:24:23","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=1957"},"modified":"2025-12-01T14:14:13","modified_gmt":"2025-12-01T13:14:13","slug":"%ce%b2-arnomad-cck2-cholecystokinin-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/%ce%b2-arnomad-cck2-cholecystokinin-receptor-cell-line\/","title":{"rendered":"<sub>\u03b2-Ar<\/sub>NOMAD CCK2 Cholecystokinin Receptor Cell Line"},"content":{"rendered":"<p>CCK receptors significantly influence neurotransmission in the brain, regulating anxiety, feeding, and locomotion. Two GPCRs known as CCK1 and CCK2 receptors composes the CCK receptors family. CCK2R gene encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. Cholecystokinin B receptor is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is present principally in the central nervous system and the gastrointestinal tract. CCK-B expression may correlate parallel to anxiety and depression phenotypes in humans.\u00a0<sub>\u03b2-Ar<\/sub>NOMAD CCK2 Cholecystokinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as CCK.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=77\">HERE<\/a> to know more about CCK2 Cholecystokinin Receptor.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p><sub>\u03b2-Ar<\/sub>NOMAD Cells are cell lines stably co-expressing tag-free GPCRs and \u03b2-arrestin Nomad Biosensor to GPCR \u03b2-arrestin modulation. Each vial of\u00a0<strong><sub>\u03b2-Ar<\/sub>NOMAD CCK2 Cholecystokinin Receptor Cell Line<\/strong> contains U2OS cells stably expressing the following constructs:<\/p>\n<ul>\n<li>human CCK2 Cholecystokinin Receptor with no tag<\/li>\n<li>\u03b2-arrestin Nomad Biosensor (Green Fluorescence)<\/li>\n<\/ul>\n<p><strong><sub>\u03b2-Ar<\/sub>NOMAD CCK2 Cholecystokinin Receptor Cell Line<\/strong> allows to assay compounds analyzing \u03b2-arrestin recruitment. When an agonist binds to CCK2R a G protein is activated which, in turn, triggers a cellular response mediated by calcium and a subsequent internalization mediated by \u00df-Arrestin. Due to the presence of \u00df-Arrestin Nomad Biosensor, this recruitment leads to an increase of green fluorescence intensity. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":1958,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[359],"product_tag":[437,430,458],"class_list":["post-1957","product","type-product","status-publish","has-post-thumbnail","product_cat-cckbr","product_tag-cholecystokinin-receptor","product_tag-gpcr","product_tag-nomad-cell-lines","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u03b2-ArNOMAD CCK2 Cholecystokinin Receptor Cell Line &#8212; \u03b2-Arrestin<\/title>\n<meta name=\"description\" content=\"Each vial of Arrestin NOMAD CCK2 Receptor Cell Line contains U2OS cells expressing CCK2R &amp; 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