Bone is a dynamic tissue, whose remodeling occurs continuously through the coordinated actions of both, osteoclasts and osteoblasts. Osteoblasts, the bone-forming cells, come from originally from pluripotent mesenchymal stem cells. They synthesize and secrete organic extracellular matrix, osteoid, whose main component is type I collagen. Osteoid is calcified by osteoblasts and during this process the cells become encased in lacunae within the calcified material and become osteocytes. Human Osteoblasts express protease-activated receptor-1 and vascular endothelial cell growth factor. Leukemia inhibitory factor can bind to the osteoblast cell surface and induce bone formation both in vitro and in vivo. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation.<\/p>\n
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Human Osteoblasts<\/strong> (HO) provided by Innoprot are isolated from human healthy calvariae or femur. HO are cryopreserved at passage one and delivered frozen. Each vial of Human Osteoblasts contains more than 500.000 viable cells. They are guaranteed to further expand for 15 population doublings following the instructions provided in the technical sheet.<\/p>\n Innoprot also offers optimized medium and reagents for the growth of\u00a0Human Osteoblasts<\/strong> which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HO culture. When ordering, you can select between Human Calvarial Osteoblasts and Human Femoral Osteoblasts.<\/p>\n <\/p>\n Size\/Quantity:<\/strong> 500.000 Cells \/ vial<\/p>\n","protected":false},"featured_media":2555,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[104],"product_tag":[465,204,506],"class_list":["post-2554","product","type-product","status-publish","has-post-thumbnail","product_cat-skeletal-cell-system-human-primary-cells","product_tag-human-primary-cells","product_tag-osteoblasts","product_tag-skeletal-cells","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"acf":[],"yoast_head":"\n