{"id":4016,"date":"2019-10-24T22:40:01","date_gmt":"2019-10-24T20:40:01","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=4016"},"modified":"2025-12-01T15:04:15","modified_gmt":"2025-12-01T14:04:15","slug":"mpxnomad-nk2-tachykinin-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-nk2-tachykinin-receptor-cell-line\/","title":{"rendered":"<sub>MPX<\/sub>NOMAD NK2 Tachykinin Receptor Cell Line"},"content":{"rendered":"<p>The tachykinin receptor NK2 (TACR2) also known as neurokinin 2 receptor (NK2R)\u00a0 is a GPCR. This gene encodes the receptor for the tachykinin neuropeptide substance K; also referred to as neurokinin A, although it has some affinity for other tachykinins. The protein is the product of the TACR2 gene. Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.\u00a0<sub>MPX<\/sub>NOMAD NK2 Tachykinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Substance P.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=361\">HERE<\/a> to know more about NK2 Receptor.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p><sub>MPX<\/sub>NOMAD Cells are cell lines stably co-expressing tag-free GPCRs and two Nomad Biosensors to monitor both G-protein pathways. Each vial of <strong><sub>MPX<\/sub>NOMAD NK2 Tachykinin Receptor Cell Line<\/strong> contains U2OS cells stably expressing the following constructs:<\/p>\n<ul>\n<li>human NK2 Receptor with no tag<\/li>\n<li>Calcium Nomad Biosensor (Green Fluorescence)<\/li>\n<li>cAMP Nomad Biosensor (Red Fluorescence)<\/li>\n<\/ul>\n<p><strong><sub>MPX<\/sub>NOMAD NK2 Receptor Cell Line<\/strong> allows to assay compounds analyzing both signalling pathways involving receptor activation; both G proteins by Ca<sup>2+<\/sup> &amp; cAMP flux, hence allowing biased activity studies. When an agonist binds to NK2 Receptor two G proteins are activated which, in turn, triggers a cellular response mediated by calcium and cAMP. This leads to an increase of fluorescence intensity of both cAMP and Ca<sup>2+<\/sup> biosensors. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":4017,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[419],"product_tag":[430,458,789],"class_list":["post-4016","product","type-product","status-publish","has-post-thumbnail","product_cat-tacr2-nk2","product_tag-gpcr","product_tag-nomad-cell-lines","product_tag-tachykinin-receptors","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MPXNOMAD NK2 Tachykinin Receptor Cell Line - GPCR Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of MPXNOMAD NK2 Tachykinin Receptor Cell Line contains U2OS cells expressing NK2 receptor &amp; two Nomad Biosensors to monitor Calcium &amp; \u03b2-arrestin.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/mpxnomad-nk2-tachykinin-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MPXNOMAD NK2 Tachykinin Receptor Cell Line - 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