{"id":4038,"date":"2019-10-25T20:17:47","date_gmt":"2019-10-25T18:17:47","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=4038"},"modified":"2025-12-01T15:07:00","modified_gmt":"2025-12-01T14:07:00","slug":"campnomad-vpac1-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/campnomad-vpac1-receptor-cell-line\/","title":{"rendered":"<sub>cAMP<\/sub>NOMAD VPAC1 Receptor Cell Line"},"content":{"rendered":"<p>Vasoactive intestinal polypeptide receptor 1, aka VPAC1, encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. VPAC1 is present in several tissues; such as brain, lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis. VIP plays an imporatnt role in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. VIP acts in an autocrine fashion via VPAC1 to inhibit megakaryocyte proliferation and induce proplatelet formation. Patients with idiopathic achalasia show a significant difference in the distribution of SNPs affecting VIPR1. <sub>cAMP<\/sub>NOMAD VPAC1 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as PACAP-38.<\/p>\n<p>Click <a href=\"http:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=371\">HERE<\/a> to know more about VIPR1 Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><sub>cAMP<\/sub>NOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of <strong><sub>cAMP<\/sub>NOMAD VPAC1 Receptor Cell Line<\/strong> contains U2OS cells stably expressing the following constructs:<\/p>\n<ul>\n<li>Human VIP Receptor 1 (VPAC1R) with no tag<\/li>\n<li>cAMP Nomad Biosensor (Red Fluorescence)<\/li>\n<\/ul>\n<p><strong><sub>cAMP<\/sub>NOMAD VPAC1 Receptor Cell Line<\/strong> allows to assay compounds analyzing the G-Protein signalling pathway by Gs involving receptor activation. When an agonist binds to VPAC1 receptor, the Gs protein is activated which, in turn, triggers a cellular response mediated by cAMP via adenylate cyclase stimulation. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":4041,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[426],"product_tag":[430,458,792],"class_list":["post-4038","product","type-product","status-publish","has-post-thumbnail","product_cat-vpac1r","product_tag-gpcr","product_tag-nomad-cell-lines","product_tag-vip-and-pacap-receptors","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>cAMPNOMAD VPAC1 Receptor Cell Line &#8212; GPCR Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of cAMP-NOMAD VPAC1 Receptor Cell Line contains U2OS cells expressing VPAC1 receptor &amp; cAMP-Nomad Biosensor to monitor its activation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/campnomad-vpac1-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"cAMPNOMAD VPAC1 Receptor Cell Line &#8212; GPCR Cell Lines\" \/>\n<meta property=\"og:description\" content=\"Each vial of cAMP-NOMAD VPAC1 Receptor Cell Line contains U2OS cells expressing VPAC1 receptor &amp; cAMP-Nomad Biosensor to monitor its activation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/innoprot.com\/es\/producto\/campnomad-vpac1-receptor-cell-line\/\" \/>\n<meta property=\"og:site_name\" content=\"Innoprot\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-01T14:07:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/innoprot.com\/wp-content\/uploads\/2019\/10\/vpac1-web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/campnomad-vpac1-receptor-cell-line\\\/\",\"url\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/campnomad-vpac1-receptor-cell-line\\\/\",\"name\":\"cAMPNOMAD VPAC1 Receptor Cell Line &#8212; 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