{"id":4045,"date":"2019-10-25T20:42:37","date_gmt":"2019-10-25T18:42:37","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=4045"},"modified":"2025-12-01T15:08:54","modified_gmt":"2025-12-01T14:08:54","slug":"campnomad-vpac2-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/campnomad-vpac2-receptor-cell-line\/","title":{"rendered":"<sub>cAMP<\/sub>NOMAD VPAC2 Receptor Cell Line"},"content":{"rendered":"<p>Vasoactive intestinal polypeptide receptor 2 (VPAC2) encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. VPAC2 Receptor is present throughout the body and is also present in a variety of human neoplastic tissues. VPAC2 may play a role in schizophrenia, and the the abnormal expression of VIPR2 messenger RNA in gallbladder tissue may play a role in the formation of gall stones and polyps. <sub>cAMP<\/sub>NOMAD VPAC2 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as PACAP-38.<\/p>\n<p>Click <a href=\"https:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=372&amp;familyId=67&amp;familyType=GPCR\">HERE<\/a> to know more about VPAC2 Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><sub>cAMP<\/sub>NOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of <strong><sub>cAMP<\/sub>NOMAD VPAC2 Receptor Cell Line<\/strong> contains U2OS cells stably expressing the following constructs:<\/p>\n<ul>\n<li>human VIP Receptor 2 (VPAC2R) with no tag<\/li>\n<li>cAMP Nomad Biosensor (Red Fluorescence)<\/li>\n<\/ul>\n<p><strong><sub>cAMP<\/sub>NOMAD VPAC2 Receptor Cell Line<\/strong> allows to assay compounds analyzing the G-Protein signalling pathway by Gs involving receptor activation. When an agonist binds to PACAP-38, the Gs protein is activated which, in turn, triggers a cellular response mediated by cAMP via adenylate cyclase stimulation. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":4048,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[427],"product_tag":[430,458,792],"class_list":["post-4045","product","type-product","status-publish","has-post-thumbnail","product_cat-vpac2r","product_tag-gpcr","product_tag-nomad-cell-lines","product_tag-vip-and-pacap-receptors","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>cAMPNOMAD VPAC2 Receptor Cell Line &#8212; GPCR Cell Lines<\/title>\n<meta name=\"description\" content=\"Each vial of cAMP-NOMAD VPAC2 Receptor Cell Line contains U2OS cells expressing VPAC2 receptor &amp; cAMP-Nomad Biosensor to monitor its activation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/campnomad-vpac2-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"cAMPNOMAD VPAC2 Receptor Cell Line &#8212; GPCR Cell Lines\" \/>\n<meta property=\"og:description\" content=\"Each vial of cAMP-NOMAD VPAC2 Receptor Cell Line contains U2OS cells expressing VPAC2 receptor &amp; cAMP-Nomad Biosensor to monitor its activation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/innoprot.com\/es\/producto\/campnomad-vpac2-receptor-cell-line\/\" \/>\n<meta property=\"og:site_name\" content=\"Innoprot\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-01T14:08:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/innoprot.com\/wp-content\/uploads\/2019\/10\/vpac2-web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/campnomad-vpac2-receptor-cell-line\\\/\",\"url\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/campnomad-vpac2-receptor-cell-line\\\/\",\"name\":\"cAMPNOMAD VPAC2 Receptor Cell Line &#8212; 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