Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of both; upper and lower motoneurons in the brain and the spinal cord. ALS and other neurodegenerative disorders, such as Alzheimer\u2019s and Parkinson\u2019s disease, are characterized by defects in protein processing resulting in protein misfolding, mislocalization and inclusion formation in motor neurons. Classical neuropathological hallmarks of ALS include ubiquitinated inclusions containing the disordered TDP-43 and FUS proteins; although pathology can be heterogeneous with the appearance of other protein aggregates. Mutations in more than forty genes have been reported to associate with ALS.<\/p>\n
SOD1 is a ubiquitously expressed protein, existing as a homodimer of 32 kDa. Each monomer is highly structured, and intramolecular disulfide bridges increase their stability. The enzyme catalizes the disproportionation of superoxide species to hydrogen peroxide and dioxygen. Fluorescent SOD1 cell line is a useful tool to assay compounds or analyze their capability to modulate superoxide dismutase 1 activity.<\/p>\n","protected":false},"excerpt":{"rendered":"
Novel fluorescent HEK293 cell lines have been developed through stable transfection with tGFP-SOD1 and FP602-SOD1. Fluorescent SOD1 Cell lines are stably-transfected and they are ready to use in cell-based assay applications. Both stably transfected cell lines provide consistent levels of expression, which helps to simplify the interpretation of the results. These cell lines are intended to be used as an \u201cin vitro\u201d model for research studies.<\/p>\n
Each vial of both, Green and Red fluorescent SOD1 Cell lines contains 3 million cells. It is guaranteed that these cells will expand in more than 30 passages following the cell culture manual.<\/p>\n","protected":false},"featured_media":8303,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[114],"product_tag":[],"class_list":["post-8302","product","type-product","status-publish","has-post-thumbnail","product_cat-stable-cell-lines-for-cns-research","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"acf":[],"yoast_head":"\n