{"id":8311,"date":"2023-03-18T14:27:57","date_gmt":"2023-03-18T13:27:57","guid":{"rendered":"http:\/\/innoprot.com\/?post_type=product&#038;p=8311"},"modified":"2025-12-01T14:58:18","modified_gmt":"2025-12-01T13:58:18","slug":"mpxnomad-s1p3-lysophospholipid-receptor-cell-line","status":"publish","type":"product","link":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/","title":{"rendered":"<sub>MPX<\/sub>NOMAD S1P3 Lysophospholipid Receptor Cell Line"},"content":{"rendered":"<p>Sphingosine-1-phosphate receptor 3 (S1PR3) gene encodes a member of the EDG family of receptors, part of G protein-coupled receptors. This protein is a functional receptor for sphingosine 1-phosphate and likely contributes to both; the regulation of angiogenesis and also the vascular endothelial cell function. Sphingosine 1-phosphate (S1P) influences heart rate, coronary artery caliber, endothelial integrity, and also lymphocyte recirculation through five related high affinity GPCRs. S1P receptor function in the immune system has experimental advantages in approaching selective S1P receptor function at vascular interfaces. Depletion of S1P<sub>3<\/sub> receptors results in a dramatic inhibition of S1P-induced neurite retraction but, on the contrary results with a significant elongation of neuronal processes in response to S1P. <sub>MPX<\/sub>NOMAD S1P3 Lysophospholipid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as S1P.<\/p>\n<p>Click <a href=\"https:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=277\">HERE<\/a> to know more about S1P3 Receptor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><sub>MPX<\/sub>NOMAD Cells are cell lines stably co-expressing tag-free GPCRs and two Nomad Biosensors to monitor G-protein and \u03b2-arrestin modulation. Each vial of <strong><sub>MPX<\/sub>NOMAD S1P3 Lysophospholipid Receptor Cell Line<\/strong> contains HEK293 cells stably expressing the following constructs:<\/p>\n<ul>\n<li>human S1P3 Lysophospholipid Receptor with no tag<\/li>\n<li>cAMP Nomad Biosensor (Red Fluorescence)<\/li>\n<li>\u03b2-arrestin Nomad Biosensor (Green Fluorescence)<\/li>\n<\/ul>\n<p><strong><sub>MPX<\/sub>NOMAD S1P3 Lysophospholipid Receptor Cell Line<\/strong> allows to assay compounds analyzing both signalling pathways involving receptor activation; G protein by cAMP flux and \u03b2-arrestin recruitment, hence allowing biased activity studies. When an agonist binds to S1P3R a G protein is activated which, in turn, triggers a cellular response mediated by cAMP and a subsequent internalization mediated by \u00df-Arrestin. This leads to an increase of fluorescence intensity of both \u03b2-Arrestin and cAMP biosensors. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Size\/Quantity<\/strong>: 2 vials containing 3&#215;10<sup>6<\/sup> cells \/ vial<\/p>\n","protected":false},"featured_media":8312,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[384],"product_tag":[],"class_list":["post-8311","product","type-product","status-publish","has-post-thumbnail","product_cat-s1p3r","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line &#8212; Innoprot<\/title>\n<meta name=\"description\" content=\"Each vial of MPXNOMAD S1PR3 Receptor Cell Line contains HEK293 cells expressing S1PR3 &amp; two Nomad Biosensors to monitor cAMP &amp; \u03b2-arrestin.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line &#8212; Innoprot\" \/>\n<meta property=\"og:description\" content=\"Each vial of MPXNOMAD S1PR3 Receptor Cell Line contains HEK293 cells expressing S1PR3 &amp; two Nomad Biosensors to monitor cAMP &amp; \u03b2-arrestin.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/\" \/>\n<meta property=\"og:site_name\" content=\"Innoprot\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-01T13:58:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/innoprot.com\/wp-content\/uploads\/2023\/03\/s1pr3-grafica.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/\",\"url\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/\",\"name\":\"MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line &#8212; Innoprot\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/innoprot.com\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/s1pr3-grafica.jpg\",\"datePublished\":\"2023-03-18T13:27:57+00:00\",\"dateModified\":\"2025-12-01T13:58:18+00:00\",\"description\":\"Each vial of MPXNOMAD S1PR3 Receptor Cell Line contains HEK293 cells expressing S1PR3 & two Nomad Biosensors to monitor cAMP & \u03b2-arrestin.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/#primaryimage\",\"url\":\"https:\\\/\\\/innoprot.com\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/s1pr3-grafica.jpg\",\"contentUrl\":\"https:\\\/\\\/innoprot.com\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/s1pr3-grafica.jpg\",\"width\":500,\"height\":500,\"caption\":\"S1PR3 Cell Line\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/producto\\\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\\\/\\\/innoprot.com\\\/es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Productos\",\"item\":\"https:\\\/\\\/innoprot.com\\\/es\\\/productos\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/innoprot.com\\\/es\\\/\",\"name\":\"Innoprot\",\"description\":\"Speeding up drug discovery\",\"publisher\":{\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/#organization\"},\"alternateName\":\"Innoprot\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/innoprot.com\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/#organization\",\"name\":\"Innoprot\",\"alternateName\":\"Innoprot\",\"url\":\"https:\\\/\\\/innoprot.com\\\/es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/innoprot.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/logo-blanco-innoprot-1.png\",\"contentUrl\":\"http:\\\/\\\/innoprot.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/logo-blanco-innoprot-1.png\",\"width\":201,\"height\":54,\"caption\":\"Innoprot\"},\"image\":{\"@id\":\"https:\\\/\\\/innoprot.com\\\/es\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line &#8212; Innoprot","description":"Each vial of MPXNOMAD S1PR3 Receptor Cell Line contains HEK293 cells expressing S1PR3 & two Nomad Biosensors to monitor cAMP & \u03b2-arrestin.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/","og_locale":"es_ES","og_type":"article","og_title":"MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line &#8212; Innoprot","og_description":"Each vial of MPXNOMAD S1PR3 Receptor Cell Line contains HEK293 cells expressing S1PR3 & two Nomad Biosensors to monitor cAMP & \u03b2-arrestin.","og_url":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/","og_site_name":"Innoprot","article_modified_time":"2025-12-01T13:58:18+00:00","og_image":[{"width":500,"height":500,"url":"https:\/\/innoprot.com\/wp-content\/uploads\/2023\/03\/s1pr3-grafica.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/","url":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/","name":"MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line &#8212; Innoprot","isPartOf":{"@id":"https:\/\/innoprot.com\/es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/#primaryimage"},"image":{"@id":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/#primaryimage"},"thumbnailUrl":"https:\/\/innoprot.com\/wp-content\/uploads\/2023\/03\/s1pr3-grafica.jpg","datePublished":"2023-03-18T13:27:57+00:00","dateModified":"2025-12-01T13:58:18+00:00","description":"Each vial of MPXNOMAD S1PR3 Receptor Cell Line contains HEK293 cells expressing S1PR3 & two Nomad Biosensors to monitor cAMP & \u03b2-arrestin.","breadcrumb":{"@id":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/#primaryimage","url":"https:\/\/innoprot.com\/wp-content\/uploads\/2023\/03\/s1pr3-grafica.jpg","contentUrl":"https:\/\/innoprot.com\/wp-content\/uploads\/2023\/03\/s1pr3-grafica.jpg","width":500,"height":500,"caption":"S1PR3 Cell Line"},{"@type":"BreadcrumbList","@id":"https:\/\/innoprot.com\/es\/producto\/mpxnomad-s1p3-lysophospholipid-receptor-cell-line\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/innoprot.com\/es\/"},{"@type":"ListItem","position":2,"name":"Productos","item":"https:\/\/innoprot.com\/es\/productos\/"},{"@type":"ListItem","position":3,"name":"MPXNOMAD S1P3 Lysophospholipid Receptor Cell Line"}]},{"@type":"WebSite","@id":"https:\/\/innoprot.com\/es\/#website","url":"https:\/\/innoprot.com\/es\/","name":"Innoprot","description":"Speeding up drug discovery","publisher":{"@id":"https:\/\/innoprot.com\/es\/#organization"},"alternateName":"Innoprot","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/innoprot.com\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/innoprot.com\/es\/#organization","name":"Innoprot","alternateName":"Innoprot","url":"https:\/\/innoprot.com\/es\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/innoprot.com\/es\/#\/schema\/logo\/image\/","url":"http:\/\/innoprot.com\/wp-content\/uploads\/2025\/03\/logo-blanco-innoprot-1.png","contentUrl":"http:\/\/innoprot.com\/wp-content\/uploads\/2025\/03\/logo-blanco-innoprot-1.png","width":201,"height":54,"caption":"Innoprot"},"image":{"@id":"https:\/\/innoprot.com\/es\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/product\/8311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/comments?post=8311"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/media\/8312"}],"wp:attachment":[{"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/media?parent=8311"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/product_brand?post=8311"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/product_cat?post=8311"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/innoprot.com\/es\/wp-json\/wp\/v2\/product_tag?post=8311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}