Innoprot offers different cell lines stably expressing GPCRs to monitor their activation through different pathways:

  • HiTSeeker Cell Lines express GPCR with no tag
  • Internalization Cell Lines express GPCR tagged to tGFP to monitor internalization assays.
  • Nomad Cell Lines co-express GPCR with no tag and Nomad Biosensors to monitor simultaneously the different GPCR signalling pathways (β-arrestin recruitment, Ca2+, cAMP or also DAG).

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Adenosine A2B Receptor Cell Line

HiTSeeker Adenosine A2B Receptor Cell Line

5.250,00

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker Adenosine A2B Receptor Cell Line contains HEK293 cells stably expressing ADORA2B with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker ADORA2B Cell Line allows to assay compounds, or analyze their capability to modulate ADORA2B. When a ligand binds to the ADORA2B, it activates a G protein, which in turn, triggers a cellular response mediated by cAMP. HiTSeeker ADORA2B cell line has been validated measuring cAMP concentration changes in the cytosol upon activation with NECA. The high reproducibility of this assay allows monitoring ADORA2B receptor activation process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial