Innoprot offers different cell lines stably expressing GPCRs to monitor their activation through different pathways:

  • HiTSeeker Cell Lines express GPCR with no tag
  • Internalization Cell Lines express GPCR tagged to tGFP to monitor internalization assays.
  • Nomad Cell Lines co-express GPCR with no tag and Nomad Biosensors to monitor simultaneously the different GPCR signalling pathways (β-arrestin recruitment, Ca2+, cAMP or also DAG).

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HiTSeeker Cholecystokinin A receptor Cell LineHiTSeeker Vasopressin Receptor 1A Cell Line

HiTSeeker Cholecystokinin A receptor Cell Line

5.250,00€

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker Cholecystokinin A receptor Cell Line contains U2OS cells stably expressing CCKAR with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker CCKAR Cell Line allows to assay compounds, or analyze their capability to modulate CCKAR. When a ligand binds to the CCKAR, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker CCKAR cell line has been validated measuring calcium concentration changes in the cytosol upon activation with CCK. The high reproducibility of this assay allows monitoring CCKAR receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×106 cells / vial

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