Innoprot offers different cell lines stably expressing GPCRs to monitor their activation through different pathways:

  • HiTSeeker Cell Lines express GPCR with no tag
  • Internalization Cell Lines express GPCR tagged to tGFP to monitor internalization assays.
  • Nomad Cell Lines co-express GPCR with no tag and Nomad Biosensors to monitor simultaneously the different GPCR signalling pathways (β-arrestin recruitment, Ca2+, cAMP or also DAG).

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Fluorescent FPR2/ALX Formylpeptide Receptor

Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line


Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line contains U2OS cells stably expressing FPR2/ALX tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line allows to assay compounds, or analyze their capability to modulate FPR2/ALX activation and the following redistribution process inside the cells. When a ligand binds to the FPR2/ALX Formylpeptide Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent FPR2/ALX redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring FPR2/ALX Formylpeptide Receptor redistribution process in High Throughput Screening.


Size/Quantity: 2 vials containing 3×106 cells / vial