Innoprot offers different cell lines stably expressing GPCRs to monitor their activation through different pathways:

  • HiTSeeker Cell Lines express GPCR with no tag
  • Internalization Cell Lines express GPCR tagged to tGFP to monitor internalization assays.
  • Nomad Cell Lines co-express GPCR with no tag and Nomad Biosensors to monitor simultaneously the different GPCR signalling pathways (β-arrestin recruitment, Ca2+, cAMP or also DAG).

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TSH Receptor Cell Line

HiTSeeker TSH Receptor Cell Line

5.250,00

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker TSH Receptor Cell Line contains HEK293 cells stably expressing human thyroid-stimulating hormone receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker TSH Receptor Cell Line allows to assay compounds, or analyze their capability to modulate TSHR. When a ligand binds to the TSHR, it activates a G protein, which in turn, triggers a cellular response mediated by second messengers (cAMP). HiTSeeker TSH Receptor cell line has been validated measuring cAMP concentration changes in the cytosol upon activation with rhTSH. The high reproducibility of this assay allows monitoring TSH receptor activation process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial