Innoprot offers different cell lines stably expressing GPCRs to monitor their activation through different pathways:

  • HiTSeeker Cell Lines express GPCR with no tag
  • Internalization Cell Lines express GPCR tagged to tGFP to monitor internalization assays.
  • Nomad Cell Lines co-express GPCR with no tag and Nomad Biosensors to monitor simultaneously the different GPCR signalling pathways (β-arrestin recruitment, Ca2+, cAMP or also DAG).

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HiTSeeker 5-HT2C Serotonin Receptor Cell Line

HiTSeeker 5-HT2C Serotonin Receptor Cell Line

5.250,00

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker 5-HT2C Serotonin Receptor Cell Line contains U2OS cells stably expressing 5-HT2C Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker 5-HT2C Serotonin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate 5-HT2C receptor. When a ligand binds to the 5-HT2C receptor, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker 5-HT2C Serotonin Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with 5-HT. The high reproducibility of this assay allows monitoring 5-HT2C Receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×106 cells / vial