Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay.

Innoprot offers stable cell lines to monitor apoptosis in living cells analyzing different changes which occurr in the cells during this process; including nuclear fragmentation, mitochondrial disrutpion and caspase activation.

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Caspase 3-7 Activity Assay Cell LineCaspase 3-7 Activity Assay Cell Line

Caspase 3-7 Activity Assay Cell Line

2.950,00€

A Novel Caspase 3-7 Activity Assay Cell Line has been developed in SH-SY5Y cell line through stable transfection with a caspase 3-7 activation reporter protein endogenously linked with FP602. When caspase 3-7 is activated, link is cleavaged and FP602 change its localization appearing in the nucleus. This cell line allows to monitor apoptosis by caspase 3-7 activation, quantifying the red fluorecence intensity inside the cell nucleus.

Each vial of Caspase 3-7 Activity Assay Cell Line cell line contains 3 million cells. It is guaranteed that these cells will expand following the cell culture manual.

Size/Quantity: 1 vial containing 3×106 cells / vial

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Fluorescent Cytochrome c HEK293 Cell Line

Fluorescent Cytochrome c HEK293 Cell Line

1.995,00€

A novel Fluorescent Cytochrome c HEK293 Cell Line (HEK293/Cytc-tGFP) has been developed through stable transfection for monitoring the cellular apoptosis level througth the Cytochrome c behavior and morphologicall changes in cell-based assays.
HEK293/Cytc-tGFP cell line was obtained by transfection of an expression vector for a fusion protein of mitochondria localization signal from Cytochrome and turboGFP.

Each vial of HEK293/Cytc-tGFP cell line contains 3 million cells. It is guaranteed that these cells will expand in more than 30 passages following the cell culture manual.

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Fluorescent LMNB1 Cell Line

Fluorescent LMNB1 Cell Line

2.950,00€

Novel Red Fluorescent LMNB1 Cell Lines have been developed through stable transfection with LMNB1 endogenously tagged with TagRFP in U2OS & SH-SY5Y cell lines. Both cell lines allow the monitorization of cellular apoptosis level through nuclear lamin B1 morphological changes in cell-based assays.

Each vial of both U2OS/LMNB1-TagRFP and SH-SY5Y/LMNB1-TagRFP cell lines contains 3 million cells. It is guaranteed that these cells will expand following the cell culture manual.

 

Size/Quantity: 1 vial containing 3×106 cells / vial

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Fluorescent Mitochondria U2OS Cell Line

Fluorescent Mitochondria U2OS Cell Line

2.650,00€

Fluorescent Mitochondria U2OS Cell Line has been developed transfecting an expression vector that encodes turbo green fluorescent protein (tGFP) fused to mitochondrial targeting sequence (MTS) derived from the subunit VIII of human cytochrome C oxidase. MTS is fused to the tGFP N-terminus and stably transfected into U2OS Cell Line. This cell line allows monitoring morphological changes in cells during mitochondrial damage.

Each vial of Fluorescent Mitochondria U2OS Cell Line contains 3 million cells. It is guaranteed that these cells will expand following the cell culture manual.

 

Size/Quantity: 1 vial containing 3×106 cells / vial

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Fluorescent Nuclear Localization Signal Cell LineFluorescent Nuclear Localization Signal Cell Line

Fluorescent Nuclear Localization Signal Cell Line

2.950,00€

Novel Green Fluorescent Nuclear Localization Signal Cell Lines have been developed through stable transfection of turboGFP tagged in the N-terminal with the NLS in U2OS & HEK293 cell lines. Both cell lines allow the study of the translocation processes between the nucleus and the cytoplasm. Nuclear localization signals (NLS) are short peptide sequences within the amino acid sequence of nuclear cargo proteins. Commonly, the NLS sequences contain a high proportion of lysine (K) or arginine (R) aminoacids and are very similar to the first found NLS sequence in the simian virus SV40 (PKKKRKV).

Each vial of both U2OS/NLS-tGFP and HEK293/NLS-tGFP cell lines contains 3 million cells. It is guaranteed that these cells will expand following the cell culture manual.

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