cAMPNOMAD Adenosine A3 Receptor Cell Line

Reference: P70524

cAMPNOMAD Adenosine A3 Receptor Cell Line

cAMPNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of cAMPNOMAD Adenosine A3 Receptor Cell Line contains HEK293 cells stably expressing the following constructs:

  • human Adenosine A3 receptor (ADORA3) with no tag
  • cAMP Nomad Biosensor (Red Fluorescence)

cAMPNOMAD ADORA3 Cell Line allows to assay compounds analyzing the G-Protein signalling pathway by Go involving receptor activation. When an agonist binds to ADORA3, Go protein is activated which, in turn, triggers a cellular response mediated by cAMP. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.

Size/Quantity: 2 vials containing 3×106 cells / vial

9.995,00

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The adenosine A3 receptor (ADORA3) is one member of the adenosine receptor group of GPCRs with adenosine as endogenous ligand. Activation of the adenosine A3 receptor by an agonist causes binding of Gi1/2/3 or Go protein. Binding of Gi1/2/3 causes an inhibition of adenylate cyclase and, therefore, a decrease in the cAMP concentration.

Adenosine A3 Receptor mediates a cardioprotective function during cardiac ischemia, it plays roles in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, and also in both neuroprotective and neurodegenerative effects; and it may also mediate both cell proliferation and cell death

Click HERE to know more about ADORA3 Receptor.

 

  • Reference: P70524
  • Nomad Biosensors: cAMP
  • GeneBank Accesion Number: NM_000677
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice