The Gastric inhibitory polypeptide receptor (GIP Receptor), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein which is present in different tissues; including in the pancreas, stomach, small intestine or adipose tissue, but also in several regions in the CNS. Adipocytes express GIP Receptors, where they modulate lipid accumulation.
Enteroendocrine K cells present in the duodenum and proximal jejunum secrete its natural ligand, the GIP, which is a 42–amino acid peptide. It has insulin-releasing and extrapancreatic glucoregulatory actions. GIP levels rise immediately after nutrient ingestion, leading to modest inhibitory effects on gastric acid secretion and gastrointestinal motility. cAMPNOMAD GIP Receptor Cell Line (GIPR Cell Line) allows the measurement of the activity of ligands, such as GIP.
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