The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein which are present in beta cells of the pancreas; and also on neurons of the brain. It plays an important role in the control of blood sugar level by enhancing insulin secretion. It is a member of the glucagon receptor family of GPCRs. GLP1R comprises two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism. cAMPNOMAD GLP-1 Receptor Cell Line (GLP1R Cell Line) allows the measurement of the activity of ligands, such as GLP-1.
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