cAMPNOMAD GLP-2 Receptor Cell Line

Reference: P70514

cAMPNOMAD GLP-2 Receptor Cell Line

cAMPNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of cAMPNOMAD GLP-2 Receptor Cell Line contains U2OS cells stably expressing the following constructs:

  • human GLP-2 Receptor (GLP2R) with no tag
  • cAMP Nomad Biosensor (Red Fluorescence)

cAMPNOMAD GLP-2 Receptor Cell Line allows to assay compounds analyzing the G-Protein signalling pathway by Gs involving receptor activation. When an agonist binds to GLP-2, the Gs protein is activated which, in turn, triggers a cellular response mediated by cAMP via adenylate cyclase stimulation. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.

Size/Quantity: 2 vials containing 3×106 cells / vial

9.995,00

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The Glucagon-like peptide-2 receptor (GLP2 Receptor) is a GPCR superfamily member closely related to the glucagon receptor (GLP1 receptor). This is a receptor for glucagon-like peptide 2. GLP2 is a 33-amino acid proglucagon peptide subproduct and the intestinal enteroendocrine cells release it. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R is present in the gut and in enteroendocrine cells in the intestinal tract. cAMPNOMAD GLP-2 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as GLP2.

Click HERE to know more about GLP-2 Receptor.

  • Reference: P70514
  • Nomad Biosensors: cAMP
  • GeneBank Accesion Number: BC096261
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice