The muscarinic acetylcholine receptor family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. Muscarinic Acetylcholine Receptor M5 has a discrete expression profile appearing predominantly on dopamine neuron terminals; within the dorsal and ventral striatum that potentiate the release of dopamine and glutamate from midbrain projections. It is the sole mAChR in dopaminergic neurons of the ventral tegmental area and substantia nigra pars compacta. Furthermore, the M5 mAChR appears densely in the ventral subiculum; which projects to the NAc shell, an input pathway implicated in context-mediated relapse to ethanol seeking. DAGNOMAD Muscarinic Acetylcholine Receptor M5 Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as oxotremorine.
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