Green fluorescent alpha-synuclein SH-SY5Y Cell line

Reference: P30707

Green fluorescent alpha-synuclein SH-SY5Y Cell line

Novel green fluorescent SH-SY5Y cell lines have been developed through stable transfection with TagGPF2-α-synuclein; including wild type α-synuclein but also A30P, E35K and A53T mutant variants. TagGFP2- α-synuclein cell lines are stably-transfected and it is ready to use in cell-based assay applications. These stably transfected cell lines provide consistent levels of expression, which help to simplify the interpretation of the results. These cell lines are intended to be used as “in vitro” models for research studies.

Each vial of Green fluorescent alpha-synuclein SH-SY5Y Cell line contains 3 million cells. It is guaranteed that these cells will expand in more than 30 passages following the cell culture manual.

2.950,00

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Alpha-synuclein (also α-synuclein) is a protein whose function in the healthy brain is currently unknown. It is abundant in the brain but also appear smaller amounts in the heart, muscles, and other tissues. In the brain, alpha-synuclein appears mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals. Innoprot has developed a green fluorescent alpha-synuclein SH-SY5Y Cell line for cell-based assays applications.

Alpha-synuclein is specifically upregulated in a discrete population of presynaptic terminals of the brain during a period of acquisition-related synaptic rearrangement. Alpha-synuclein significantly interacts with tubulin, and that alpha-synuclein may have activity as a potential microtubule-associated protein, like tau. The aggregation, deposition, and dysfunction of alpha-synuclein are common events in neurodegenerative disorders, also called synucleinopathies. These include Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. Study of alpha-synuclein is crucial to test the emerging hypothesis that Parkinson’s disease affects many areas of the central nervous system beyond the substantia nigra, and even extends beyond the boundaries of the central nervous system. Different cell lines expressing both wild type mutants are available at Innoprot.

  • Reference: P30707
  • Size/Quantity: 1 vial containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice