The beta-2 adrenergic receptor (β2 adrenoreceptor); also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor. It interacts with (binds) epinephrine; a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increased cAMP, and downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Green Fluorescent beta-2 adrenoreceptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as isoproterenol.There are three differentes types of Beta2-agonists; those which directly activate the receptor (salbutamol/terbutaline), those which are present into a membrane depot (formoterol) and those which interact with a receptor-specific, auxiliary binding site (salmeterol). These differences in mechanism of action reflect the kinetics of airway smooth muscle relaxation and bronchodilation in asthmatic patients.
Click HERE to know more about β2-adrenoceptor.