Green Fluorescent Calcitonin Receptor
Green Fluorescent Calcitonin Receptor Cell Line - Image 2

Green Fluorescent Calcitonin Receptor Cell Line

Reference: P30236

6.950,00€

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent Calcitonin Receptor Cell Line contains CHO-K1 cells stably expressing CALCR tagged with tGFP.  These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent Calcitonin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CALCR activation and the following redistribution process inside the cells. When a ligand binds to the CALCR, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CALCR redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring Calcitonin Receptor redistribution process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial

The calcitonin receptor is a GPCR in the same group B sub-family that also includes the receptors for vasoactive intestinal peptide, secretin, and PTH and PTHrP. This receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. This gene encodes a high affinity receptor for the peptide hormone Calcitonin. The protein plays an important role in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Calcitonin Receptor is able to decrease blood calcium levels by both; direct inhibition of mediated bone resorption and also by enhancing calcium excretion by the kidney. Green Fluorescent Calcitonin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as calcitonin.

Click HERE to know more about Calcitonin Receptor.
  • Reference: P30236
  • Size/Quantity: 2 vials containing 3x10⁶ cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice

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