Green Fluorescent CB2 Cannabinoid Receptor Cell Line

Reference: P30208

Green Fluorescent CB2 Cannabinoid Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent CB2 Cannabinoid Receptor Cell Line contains CHO-K1 cells stably expressing CB2 tagged with tGFP.  These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent CB2 Cannabinoid Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CB2 activation and the following redistribution process inside the cells. When a ligand binds to the CB2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CB2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring CB2 Receptor redistribution process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial

6.950,00

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The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two cannabinoid receptors play and important role in the cannabinoid-induced CNS effects, including alterations in mood and cognition. Changes in endocannabinoid levels and/or CB2 receptor expressions are present in almost all diseases affecting humans; such as cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung disorders or pain and cancer. The prevalence of this trend suggests that modulating CB2 receptor activity by either selective CB2 receptor agonists or inverse agonists/antagonists depending on the disease and its progression holds unique therapeutic potential for these pathologies. Green Fluorescent CB2 Cannabinoid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as CP55940.

Click HERE to know more about CB2 Cannabinoid Receptor.

  • Reference: P30208
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice