Green Fluorescent CXCR2 Chemokine Receptor Cell Line

Reference: P30274

Green Fluorescent CXCR2 Chemokine Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent CXCR2 Chemokine Receptor Cell Line contains U2OS cells stably expressing CXCR2 tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent CXCR2 Chemokine Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CXCR2 activation and the following redistribution process inside the cells. When a ligand binds to the CXCR2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CXCR2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring CXCR2 Receptor redistribution process in High Throughput Screening.


Size/Quantity: 2 vials containing 3×106 cells / vial


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Chemokines and chemokine receptors are potential therapeutic targets for a variety of diseases. CXCR2 Chemokine receptor is the official name for the nterleukin 8 receptor, beta. This gene encodes a protein which is a member of the G-protein-coupled receptor family. This receptor binds to Interleukin 8 and chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity. Expression of CXCR2 occurs on neutrophils and oligodendrocytes playing important roles in immunity, cancer growth and CNS development; but its expression also occurs on human basophils, T-lymphocytes and endothelial cells. Green Fluorescent CXCR2 Chemokine Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as IL-8.

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  • Reference: P30274
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice