Mu, delta and kappa opioid receptors are GPCRs, which play a central role in pain control. They are key players in hedonic homeostasis, mood and well-being. The three receptors and their endogenous opioid peptides also regulate responses to stress, and a number of peripheral physiological functions including respiratory, gastrointestinal, endocrine and immune processes. Delta opioid receptors (aka δ receptors, DORs or DOP receptors) have emerged as an attractive target in many respects. DOR is present in the human central nervous system in cortical regions and limbic structures such as hippocampus and amygdala, as well as basal ganglia and hypothalamus. The stimulation of delta opioid receptors strongly reduces pain, specifically under situations of persistent pain. Fluorescent Delta Opioid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Deltorphin II.
Click HERE to know more about DOR Opioid Receptor.
