Green Fluorescent Delta Opioid Receptor Cell Line

Reference: P30232

Green Fluorescent Delta Opioid Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent Delta Opioid Receptor Cell Line contains U2OS cells stably expressing DOR Receptor tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent Delta Opioid Receptor Cell Line allows to assay compounds, or analyze their capability to modulate DOR Receptor activation and the following redistribution process inside the cells. When a ligand binds to the DOR Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent Delta Opioid Receptor redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring DOR Receptor redistribution process in High Throughput Screening.


Size/Quantity: 2 vials containing 3×106 cells / vial


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Mu, delta and kappa opioid receptors are GPCRs, which play a central role in pain control. They are key players in hedonic homeostasis, mood and well-being. The three receptors and their endogenous opioid peptides also regulate responses to stress, and a number of peripheral physiological functions including respiratory, gastrointestinal, endocrine and immune processes. Delta opioid receptors (aka δ receptors, DORs or DOP receptors) have emerged as an attractive target in many respects. DOR is present in the human central nervous system in cortical regions and limbic structures such as hippocampus and amygdala, as well as basal ganglia and hypothalamus. The stimulation of delta opioid receptors strongly reduces pain, specifically under situations of persistent pain. Fluorescent Delta Opioid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Deltorphin II.

Click HERE to know more about DOR Opioid Receptor.

  • Reference: P30232
  • DNA Accession Number: NM_000911
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice