The formyl peptide receptors (FPRs) are GPCRs that transduce chemotactic signals in phagocytes. They mediate host-defense as well as inflammatory responses including cell adhesion, migration, granule release and superoxide production. The FPR2 receptor is present on human neutrophils, eosinophils, monocytes, macrophages, T cells, synovial fibroblasts, and intestinal and airway epithelium. FPR2 is also known as the LXA4 or ALX/FPR2 receptor based on studies finding that is a high affinity receptor for the arachidonic acid metabolite, lipoxin A4 (LXA4), and thereafter for a related arachidonic acid metabolite, the Epi-lipoxin, aspirin-triggered lipoxin A4 (i.e. ATL, 15-epi-LXA4) and a docosahexaenoic acid metabolite, resolvin D1 (i.e. RvD1); these three cell-derived fatty acid metabolites act to inhibit and resolve inflammatory responses. Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as WKYMVm.
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