Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1), is a protein that in humans is encoded by the ADCYAP1R1 gene. This receptor binds pituitary adenylate cyclase activating peptide. PAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family. This receptor belongs to the family of VIP and PACAP receptors. PAC1 receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and couples to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants. PAC1 is present in different tissue, such as adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain. It is also present in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional). Green Fluorescent PAC1 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as PACAP-38.
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