Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. This receptor is a GPCR which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking. S1P1 Receptor is target for a variety of disease indications and with positive results for the treatment of patients with relapsing multiple sclerosis. Green Fluorescent S1P1 Lysophospholipid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as S1P.
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