The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR) is a transmembrane receptor present predominantly in the ovary and testis, but also in many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans). Its activation is necessary for the hormonal functioning during reproduction. In women, the hormone stimulates the ovaries to produce oestradiol. Two weeks into a woman’s cycle, a surge in luteinizing hormone causes the ovaries to release an egg during ovulation. If fertilization occurs, luteinizing hormone will stimulate the corpus luteum, which produces progesterone to sustain the pregnancy. Both hormones stimulates gonadal function in assisted conception techniques such as in vitro fertilisation (IVF). HiTSeeker LHCGR Cell Line from Innoprot allows the measurement of the activity and potency of ligands, such as recombinant human CG (rhCG).
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