HiTSeeker Melanocortin MC4 Receptor Cell Line

Reference: P30410

HiTSeeker Melanocortin MC4 Receptor Cell Line

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker Melanocortin MC4 Receptor Cell Line contains HEK293 cells stably expressing MC4R with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker MC4R Cell Line allows to assay compounds, or analyze their capability to modulate MC4R. When a ligand binds to the MC4R, it activates a G protein, which in turn, triggers a cellular response mediated by cAMP. HiTSeeker Melanocortin MC4 Receptor Cell Line has been validated measuring cAMP concentration changes in the cytosol upon activation with α-MSH. The high reproducibility of this assay allows monitoring MC4 receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×106 cells / vial


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MC4R is a membrane-bound receptor and part of the Melanocortin Receptors family, that are members of the rhodopsin family receptors. MC4R binds adrenocorticotropic and α-melanocyte stimulating hormone (α-MSH) and plays important roles in a wide range of physiological functions, such as energy balance, metabolism regulation, feeding and sexual behaviour and erectile function. Mutations in its gene link with autosomal dominant obesity. It is mainly present in brain, placenta and intestinal tissue. When α-MSH binds to its receptor, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. HiTSeeker Melanocortin MC4 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as α-MSH.

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  • Reference: P30410
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice

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