HiTSeeker TRH1 Thyrotropin-Releasing Hormone Receptor Cell Line

Reference: P30423

HiTSeeker TRH1 Thyrotropin-Releasing Hormone Receptor Cell Line

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker TRH1 Thyrotropin-Releasing Hormone Receptor Cell Line contains U2OS cells stably expressing TRH1 Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker TRH1 Thyrotropin-Releasing Hormone Receptor Cell Line allows to assay compounds, or analyze their capability to modulate TRH1 receptor. When a ligand binds to the TRH1, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker TRH Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with TRH. The high reproducibility of this assay allows monitoring rhTRH Receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×106 cells / vial


The thyrotropin-releasing hormone receptor (TRH1R) is a GPCR which binds the tripeptide thyrotropin releasing hormone. Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF) or thyroliberin, is a releasing hormone, produced by the hypothalamus, that stimulates the release of thyrotropin (thyroid-stimulating hormone or TSH) and prolactin from the anterior pituitary. It is a tropic, tripeptidal hormone. The TRH test is the clinical use of TRH by intravenous injection to check the response of the anterior pituitary gland. This is a diagnostic test of thyroid disorders such as secondary hypothyroidism and in acromegaly. TRH has also anti-depressant and anti-suicidal properties. HiTSeeker TRH Thyrotropin-Releasing Hormone Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as recombinant human TRH.

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  • Reference: P30423
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice